The production process of inositol

source:未知 date:2019-05-23 16:41 browse:

  Inositol, commonly known as cyclohexanol, is widely found in various natural animal, plant and microbial tissues. It is originally extracted from muscle tissue, so it is called inositol, also known as muscle sugar.

  Inositol formula C6H12O6, relative molecular mass of 180.16, relative density 1.752, melting point of 225 ~ 227 ℃, white crystalline powder.No smell, slightly sweet taste, its sweetness is half of sucrose, more stable in the air, easy to absorb moisture, water solution was neutral.Inositol is soluble in water, slightly soluble in alcohol, acetic acid, glycerin and ethylene glycol, insoluble in ether, chloroform, anhydrous acetone and other organic solvents.In less than 50 ℃ temperatures, can precipitate from the water of crystallization colorless monoclinic crystal edges of dihydrate, in 100 ~ 110 ℃ of anhydrous easy to dehydration.

  2 production process

  2.1 pressurized hydrolysis method

  Raw materials for production of inositol of phenanthrene, Mr Dean widely exists in the seeds of plants, extraction method is generally used alkaline neutralization precipitation, dilute acid extraction with dilute mineral acid soaking raw material, and then used calcium hydroxide alkaline solution and precipitation, get paste fe dean products, due to the different raw materials, the process route is slightly different.

  Phytin is a main method to extract rice bran at present. In China, it is usually prepared by soaking rice bran with 0.1 mole of hydrochloric acid (8 ~ 9 times as much as rice bran) for 6 ~ 8h, and then releasing the soaking liquid, using lime milk as precipitant, and adjusting the pH value to about 5.8 ~ 6.0.With acid leaching rice bran at the same time, adding urea, ammonium sulfide, ammonium bicarbonate, glauber's salt, salt and other neutral salts, can prevent hydrocarbon, protein and fat dissolution, the amount of the leaching solution for 0.5% ~ 5%.

  Feiting was extracted from wheat bran.Compared with rice bran, wheat bran contains a large amount of starch, which can be directly fed to produce feltin with a yield of only 3% ~ 4%. If the starch is removed after rough grinding or sifting to prepare feltin, the yield can reach about 8%. The sifted crude starch is sold with a value higher than that of wheat bran.

  The technological process of extracting feiting from wheat bran is as follows: wheat bran rough grinding or screening acid leaching neutralization precipitation filtration washing paste feiting.

  Corn seeds contain 1.31% of fitin. In the production process of corn starch plant, a large amount of corn sulfite soaking liquid is produced, which contains 0.5% ~ 1.0% of fitin. In the past, it was discharged as waste water to pollute the environment.Feiting is prepared from corn soaking liquid, usually by means of lime milk precipitation.Remove impurities from the corn soaking liquid soaked in the heat preservation cycle for 3-4d, filter out the clear liquid, neutralize it with 10% lime milk under constant stirring, fully mix it, adjust the pH value to 5.8, and let it stand for 2h to make feiting fully precipitate out.It is more economical than rice bran and wheat bran to extract fetin from waste liquid of corn.

  Feiting is derived from corn or bean starch.For example, the content of phytin in rice bran cake was 8.03%, the extraction rate was 80%, and the yield of phytin was 52kg/ton.

  The pressurized hydrolysis method is the traditional method for the production of inositol. The slurry of fistine and water is put into the pressurized hydrolysis pot in a ratio of 1:3 ~ 3:5. Under the hydrolysis pressure of 0.5 ~ 0.6mpa, the mixture is stirred for 8 ~ 10h.

  Fresh lime milk was added in the hydrolysate for neutralization.The controlled pH value of 3~3.5 by - product calcium phosphate can be directly used as phosphate fertilizer or processed into feed additive phosphate.The neutralizing solution was added to activated carbon fiber with a solution amount of 0.5% ~ 1.5%, boiled and decolorized for 20min, and then the inositol was filtered while it was still hot.The filtered clear liquid was vacuum concentrated until the relative density was 1.28 ~ 1.30, then cooled and crystallized, centrifuged, the separated crude inositol was sent to refine, and the mother liquid was applied to recover the inositol.

  The proportion of the crude product by 1:1. 2 ~ 1.5 add distilled water, heat to dissolve, join the crude inositol system accounts for about 1.5% ~ 2.0% of the quality of inositol medicinal activated carbon, boil after decolorizing, the suction filter, filtrate cooled to about 32 ℃, crystal filter, the crystal with a small amount of anhydrous ethanol washing, inositol quick wet products.Tell the mother liquor of refining process, after concentrated into the refined process, as far as possible to reduce the loss of inositol, wet of inositol in 66 ~ 70 ℃ drying was finished.inositol

  The hydrolysis process is a key step in the production of inositol.The yield of the low inositol hydrolysis process at low temperature and low pressure is up to 2% ~ 3%. At present, the pressure hydrolysis process is generally adopted at home and abroad, and the working pressure used is mostly 0.3 ~ 0.8mpa, and 1.5 ~ 2.5mpa abroad.Increasing the reaction pressure can shorten the hydrolysis cycle and increase the product yield.Hydrolysis reaction of the key factors is the hydrolysis of slurry pH value, reaction temperature and operating pressure, the hydrolysis of slurry pH value of 4.5, hydrolysis temperature 170 ~ 180 ℃, pressure is 0.7 ~ 0.8 MPa, under the condition of hydrolysis of 8 ~ 9 h, the yield can reach more than 95%.

  Most domestic manufacturers use calcium carbonate compound additive in the hydrolysis process, the addition of inositol into the additive can improve the hydrolysis rate, reduce the loss of inositol, and is conducive to improving the product quality, the amount of addition is generally about 5%.The addition of calcium carbonate could reduce hydrolysate of soluble phosphate and phosphate, more generate insoluble phosphate, prompted the hydrolysis speed, hydrolysis, reduce the burden of neutralization desalination, hydrolyzed in addition add calcium carbonate can make pH above 5, reduced the hydrolysate of equipment corrosion, but at some stage of hydrolysis process will produce large amounts of carbon dioxide to make pressure rise quickly, hydrolysis kettle explosion-proof device installation.

  Phytin hydrolyzes to form inositol, insoluble calcium phosphate and soluble calcium dihydrogen phosphate, calcium hydrophosphate and a small amount of phosphoric acid.In the traditional process, the precipitant is the oxide and hydroxide of alkaline earth metal, which are all used alone. It is difficult to master many factors, such as the concentration of precipitant, adding method, control of pH value and determination of neutralization terminal point.The process of neutralizing and desalting with compound precipitant can avoid the formation of inositol complex, make the reaction stable, control the pH value well, and reduce the loss of inositol in the desalting process.

  The purpose of refining is to remove ions and pigment impurities contained in crude inositol.Domestic manufacturers generally use reagents in addition to impurity, it has the advantages of simple operation, low cost.

  Specific operation as follows: under the 80 ~ 90 ℃, join the decolorizing activated carbon fiber to colorless transparent.After decolorization, add Ba(OH)2 and oxalic acid at pH 7.0 ~ 8.0, add a small amount of Ba(OH)2 first, a few minutes later, add a small amount of oxalic acid, the pH value is strictly controlled in 7.0 ~ 8.0, in order to avoid introducing other impurities, activated carbon and oxalic acid need to be treated in advance.In order to further improve the purity to meet the requirements of the pharmacopoeia, the method described above should be followed for further refining.

  The method of removing impurity that abroad USES commonly is ion exchange resin method, remove cationic ion through cationic exchange resin column, remove acid radical ion through anion exchange resin column again, through such processing, the quality of inositol and yield will have bigger rise, and 1 time crystallization obtains pure product inositol.The product loss can be reduced by using ion exchange resin, and the yield can be increased by 2% ~ 4% compared with the conventional method.The impurity ion is completely removed, the quality of inositol products is better, and there is no need to use ammonium oxalate, barium hydroxide, activated carbon and other raw materials, shortened the process, large processing capacity, suitable for mass production of inositol, but resin regeneration cost is higher.